Search and Capture Efficiency of Dynamic Microtubules for Centrosome Relocation during IS Formation.

ABSTRACT: Upon contact with antigen-presenting cells, cytotoxic T lymphocytes (T cells) establish a highly organized contact zone denoted as the immunological synapse (IS). The formation of the IS implies relocation of the microtubule organizing center (MTOC) toward the contact zone, which necessitates a proper connection between the MTOC and the IS via dynamic microtubules (MTs). The efficiency of the MTs finding the IS within the relevant timescale is, however, still illusive. We investigate how MTs search the three-dimensional constrained cellular volume for the IS and bind upon encounter to dynein anchored at the IS cortex. The search efficiency is estimated by calculating the time required for the MTs to reach the dynein-enriched region of the IS. In this study, we develop simple mathematical a

SUBMITTER: Sarkar A 

PROVIDER: S-EPMC6554458 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature