Mobility of Molecular Motors Regulates Contractile Behaviors of Actin Networks.

ABSTRACT: Cells generate mechanical forces primarily from interactions between F-actin, cross-linking proteins, myosin motors, and other actin-binding proteins in the cytoskeleton. To understand how molecular interactions between the cytoskeletal elements generate forces, a number of in vitro experiments have been performed but are limited in their ability to accurately reproduce the diversity of motor mobility. In myosin motility assays, myosin heads are fixed on a surface and glide F-actin. By contrast, in reconstituted gels, the motion of both myosin and F-actin is unrestricted. Because only these two extreme conditions have been used, the importance of mobility of motors for network behaviors has remained unclear. In this study, to illuminate the impacts of motor mobility on the contractile beha

SUBMITTER: Matsuda A 

PROVIDER: S-EPMC6554474 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature