Stiffness of MDCK II Cells Depends on Confluency and Cell Size.

ABSTRACT: Mechanical phenotyping of adherent cells has become a serious tool in cell biology to understand how cells respond to their environment and eventually to identify disease patterns such as the malignancy of cancer cells. In the steady state, homeostasis is of pivotal importance, and cells strive to maintain their internal stresses even in challenging environments and in response to external chemical and mechanical stimuli. However, a major problem exists in determining mechanical properties because many techniques, such as atomic force microscopy, that assess these properties of adherent cells locally can only address a limited number of cells and provide elastic moduli that vary substantially from cell to cell. The origin of this spread in stiffness values is largely unknown and might limi

SUBMITTER: Nehls S 

PROVIDER: S-EPMC6554486 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature