Genetic Susceptibility to Chronic Kidney Disease - Some More Pieces for the Heritability Puzzle.

ABSTRACT: Chronic kidney disease (CKD) is a major global health problem with an increasing prevalence partly driven by aging population structure. Both genomic and environmental factors contribute to this complex heterogeneous disease. CKD heritability is estimated to be high (30-75%). Genome-wide association studies (GWAS) and GWAS meta-analyses have identified several genetic loci associated with CKD, including variants in UMOD, SHROOM3, solute carriers, and E3 ubiquitin ligases. However, these genetic markers do not account for all the susceptibility to CKD, and the causal pathways remain incompletely understood; other factors must be contributing to the missing heritability. Less investigated biological factors such as telomere length; mitochondrial proteins, encoded by nuclear genes or s

SUBMITTER: Canadas-Garre M 

PROVIDER: S-EPMC6554557 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature