Febuxostat for Cerebral and CaRdiorenovascular Events PrEvEntion StuDy.

ABSTRACT:

Aims

To compare the occurrence of cerebral, cardiovascular, and renal events in patients with hyperuricaemia treated with febuxostat and those treated with conventional therapy with lifestyle modification.

Methods and results

This multicentre, prospective, randomized open-label, blinded endpoint study was done in 141 hospitals in Japan. A total of 1070 patients were included in the intention-to-treat population. Elderly patients with hyperuricaemia (serum uric acid >7.0 to ≤9.0 mg/dL) at risk for cerebral, cardiovascular, or renal disease, defined by the presence of hypertension, Type 2 diabetes, renal disease, or history of cerebral or cardiovascular disease, were randomized to febuxostat and non-febuxostat groups and were observed for 36 months. Cerebral, cardiovascular, a

SUBMITTER: Kojima S 

PROVIDER: S-EPMC6554652 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature