Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

ABSTRACT: Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial neurodegenerative phenotype (MGnD) representing two opposite ends. A number of variants in genes selectively expressed in microglia are associated with an increased risk for neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). Among these genes are progranulin (GRN) and the triggering receptor expressed on myeloid cells 2 (TREM2). Both cause neurodegeneration by mechanisms involving loss of function. We have now isolated microglia from Grn^-/- mice and compared their transcriptomes to those of Trem2^-/-mice Surprisingly, while loss of Trem2 enhances the expression of genes associated with a homeost

SUBMITTER: Gotzl JK 

PROVIDER: S-EPMC6554672 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature