Regional Heterogeneity of Lobar Ventilation in Asthma Using Hyperpolarized Helium-3 MRI.

ABSTRACT:

Rationale and objectives

To determine lobar ventilation patterns in asthmatic lungs with hyperpolarized ³He magnetic resonance imaging (HP ³He MRI).

Materials and methods

Eighty-two subjects (14 normal, 48 mild-to-moderate asthma, and 20 severe asthma) underwent HP ³He MRI, computed tomography (CT), and pulmonary function testing. After registering proton to ³He images, we segmented the lungs from proton MRI and further segmented the five lung lobes (right upper lobe [RUL], right middle lobe [RML], and right lower lobe [RLL]; left upper lobe and left lower lobe [LLL]) by referring to the lobar segmentation from CT. We classified the gas volume into four signal intensity levels as follows: ventilation defect percent (VDP), low venti

SUBMITTER: Zha W 

PROVIDER: S-EPMC6554715 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature