Transcriptome profiling revealed multiple genes and ECM-receptor interaction pathways that may be associated with breast cancer.

ABSTRACT:

Background

Exploration of the genes with abnormal expression during the development of breast cancer is essential to provide a deeper understanding of the mechanisms involved. Transcriptome sequencing and bioinformatics analysis of invasive ductal carcinoma and paracancerous tissues from the same patient were performed to identify the key genes and signaling pathways related to breast cancer development.

Methods

Samples of breast tumor tissue and paracancerous breast tissue were obtained from 6 patients. Sequencing used the Illumina HiSeq platform. All. Only perfectly matched clean reads were mapped to the reference genome database, further analyzed and annotated based on the reference genome information. Differentially expressed genes (DEGs) were identified using the DESeq

SUBMITTER: Bao Y 

PROVIDER: S-EPMC6554968 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature