A Systematic Review of Closed Head Injury Models of Mild Traumatic Brain Injury in Mice and Rats.

ABSTRACT: Mild TBI (mTBI) is a significant health concern. Animal models of mTBI are essential for understanding mechanisms, and pathological outcomes, as well as to test therapeutic interventions. A variety of closed head models of mTBI that incorporate different aspects (i.e., biomechanics) of the mTBI have been reported. The aim of the current review was to compile a comprehensive list of the closed head mTBI rodent models, along with the common data elements, and outcomes, with the goal to summarize the current state of the field. Publications were identified from a search of PubMed and Web of Science and screened for eligibility following PRISMA guidelines. Articles were included that were closed head injuries in which the authors classified the injury as mild in rats or mice. Injury model and

SUBMITTER: Bodnar CN 

PROVIDER: S-EPMC6555186 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature