MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project.

ABSTRACT: DNA damage and subsequent repair pathways have been involved in the initiation and progression of atherosclerosis. Meiotic recombination 11 homolog A (MRE11A) gene polymorphisms have been associated with the presence of myocardial infarction. We analyzed five MRE11A gene polymorphisms in 386 individuals with subclinical atherosclerosis and 1093 healthy controls. Under different models, the rs13447720 (Odds ratio = 0.646, P_additive = 0.009; Odds ratio = 0.636, P_dominant = 0.012; Odds ratio = 0.664, P_{over-dominant} = 0.025; Odds ratio = 0.655, P_codominant1 = 0.021) and rs499952 (Odds ratio = 0.807, P_additive = 0.032; Odds ratio = 0.643, P_codominant2 = 0.034) polymorphisms were associated with a lower risk of subcl

SUBMITTER: Vargas-Alarcon G 

PROVIDER: S-EPMC6555271 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature