Activity of quercetin and kaemferol against Streptococcus mutans biofilm.

ABSTRACT:

Objective

Nidus Vespae (NV) is the honeycomb of Polistes Olivaceous, P. Japonicus Saussure, and Parapolybiavaria Fabricius. Previously, we have shown the extract and chemical fractions from NV demonstrated remarkable capacities of inhibiting the acid production of oral bacteria at sub-minimum inhibitory concentration (MIC) concentrations. In searching the most potent anti-caries compounds in NV, we further separated the NV Chl/MeOH fraction and obtained two purified compounds: quercetin and kaemferol. The objective of this study was to assess the effectiveness of quercetin and kaemferol against S. mutans biofilm formation.

Methods

The MIC, minimum biofilm inhibition concentration (MBIC₅₀) and minimum biofilm reduction concentration (MBRC₅₀) against Stre

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC6555400 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature