The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women.

ABSTRACT:

Background

Higher mortality experienced by socially disadvantaged groups and/or racial/ethnic minorities is hypothesized to be, at least in part, due to an acceleration of the aging process. Using a new epigenetic aging measure, Levine DNAmAge, this study aimed to investigate whether epigenetic aging accounts for mortality disparities by race/ethnicity and education in a sample of U.S. postmenopausal women.

Methods

1834 participants from an ancillary study (BA23) in the Women's Health Initiative, a national study that recruited postmenopausal women (50-79 years) were included. Over the 22 years of follow-up, 551 women died, and 31,946 person-years were observed. Levine DNAmAge (unit in years) was calculated based on an equation that we previously developed in an independent

SUBMITTER: Liu Z 

PROVIDER: S-EPMC6555423 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature