Sexual Dimorphism of Coronary Artery Disease in a Low- and Intermediate-Risk Asymptomatic Population: Association with Coronary Vessel Wall Thickness at MRI in Women.

ABSTRACT:

Purpose

To demonstrate the association between coronary vessel wall thickness (VWT) measured at MRI and coronary artery disease (CAD) risk in asymptomatic groups at low and intermediate risk on the basis of Framingham score.

Materials and methods

A total of 131 asymptomatic adults were prospectively enrolled. All participants underwent CT angiography for scoring CAD, and coronary VWT was measured at 3.0-T MRI. Nonlinear single and multivariable regression analyses with consideration for interaction with sex were performed to investigate the association of traditional atherosclerotic risk factors and VWT with CT angiography-based CAD scores.

Results

The analysis included 62 women and 62 men with low or intermediate Framingham score of less than 20%. Age (mean age, 45.0

SUBMITTER: Ghanem AM 

PROVIDER: S-EPMC6555440 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature