The in vitro effects of gibberellin on human sperm motility.

ABSTRACT: Gibberellin, a plant growth regulator, is widely used to increase the shelf life and quality of fruits and vegetables. In this study, human semen samples were exposed to different concentrations of gibberellin, which reduced spermatozoa motility in vitro. Gibberellin exposure also increased levels of reactive oxygen species and the protein levels of apoptosis markers in human sperm. Gibberellin inhibited the activity of Na⁺/K⁺-adenosine triphosphatase (ATPase) and Ca²⁺-ATPase, which maintain the stability of ions inside and outside the membranes of spermatozoa. Moreover, gibberellin exposure suppressed adenosine triphosphate production and reduced the protein levels of adenosine triphosphate synthases, which may have induced the protein expression of

SUBMITTER: Xu CS 

PROVIDER: S-EPMC6555458 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature