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On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials.

ABSTRACT: Microfluidic manufacturing platforms have advanced the production of monodisperse, shape-controlled, and chemically defined micromaterials. However, conventional microfabrication platforms are typically designed and fabricated as single-purpose and single-use tools, which limits their efficiency, versatility, and overall potential. We here present an on-the-fly exchangeable nozzle concept that operates in a transparent, 3D, and reusable microfluidic device produced without cleanroom technology. The facile exchange and repositioning of the nozzles readily enables the production of monodisperse water-in-oil and oil-in-water emulsions, solid and core-shell microspheres, microfibers, and even Janus type micromaterials with controlled diameters ranging from 10 to 1000 ?m using a single microfluidic device.

SUBMITTER: Kamperman T

PROVIDER: S-EPMC6555637 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials.

Kamperman Tom T van Loo Bas B Gurian Melvin M Henke Sieger S Karperien Marcel M Leijten Jeroen J

Lab on a chip 20190424 11

Microfluidic manufacturing platforms have advanced the production of monodisperse, shape-controlled, and chemically defined micromaterials. However, conventional microfabrication platforms are typically designed and fabricated as single-purpose and single-use tools, which limits their efficiency, versatility, and overall potential. We here present an on-the-fly exchangeable nozzle concept that operates in a transparent, 3D, and reusable microfluidic device produced without cleanroom technology. ...[more]

PMID: 31017163

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