A neurophysiological measure of reward sensitivity and its association with anhedonia in psychiatrically healthy adolescents and young adults.

ABSTRACT: Anhedonia (i.e., the attenuated ability to enjoy pleasurable stimuli) characterizes multiple mood disorders, but its neurophysiological underpinnings are not yet clear. Here, we measured event-related potentials in 116 adolescents and young adults engaged in an asymmetric reinforcement procedure designed to objectively characterize the anhedonic phenotype. In line with previous studies, the behavioral results showed that approximately 35% of the sample did not develop a response bias towards the more frequently rewarded stimuli (a sign of low hedonic capacity). The event-related potentials (ERPs) evoked by the reward feedback stimuli delivered during the task showed that individuals that did not develop a response bias had less cortical positivity at Fz from 224 ms to 316 ms post feedback

SUBMITTER: Frank DW 

PROVIDER: S-EPMC6555656 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature