Joint associations of obesity and estimated GFR with clinical outcomes: a population-based cohort study.

ABSTRACT:

Background

Despite the interrelationships between obesity, eGFR and albuminuria, few large studies examine how obesity modifies the association between these markers of kidney function and adverse clinical outcomes.

Methods

We examined the joint associations between obesity, eGFR and albuminuria on four clinical outcomes (death, end-stage renal disease [ESRD], myocardial infarction [MI], and placement in a long-term care facility) using a population-based cohort with procedures from Alberta. Obesity was defined by body mass index ≥35 kg/m² as defined by a fee modifier applied to an eligible procedure.

Results

We studied 1,293,362 participants, of whom 171,650 (13.3%) had documented obesity (BMI ≥ 35 kg/m² based on claims data) and 1,121,712 (86.7

SUBMITTER: Tonelli M 

PROVIDER: S-EPMC6555725 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature