Airway host-microbiome interactions in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Little is known about the interactions between the lung microbiome and host response in chronic obstructive pulmonary disease (COPD).

Methods

We performed a longitudinal 16S ribosomal RNA gene-based microbiome survey on 101 sputum samples from 16 healthy subjects and 43 COPD patients, along with characterization of host sputum transcriptome and proteome in COPD patients.

Results

Dysbiosis of sputum microbiome was observed with significantly increased relative abundance of Moraxella in COPD versus healthy subjects and during COPD exacerbations, and Haemophilus in COPD ex-smokers versus current smokers. Multivariate modeling on sputum microbiome, host transcriptome and proteome profiles revealed that significant associations between Moraxella and Haemophilus,

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6555748 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature