Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Iron has been shown to promote breast carcinogenesis in animal models through generation of oxidative stress and interaction with estrogen. Heme iron, which is found exclusively in animal-sourced foods, is suggested to have a more detrimental effect. Epidemiological evidence of the association between iron and breast cancer risk remains inconclusive and has not been comprehensively summarized. This systematic review and meta-analysis evaluated associations between both iron intake and body iron status and breast cancer risk.

Methods

Four electronic databases (MEDLINE, EMBASE, CINAHL, and Scopus) were searched up to December 2018 for studies assessing iron intake and/or biomarkers of iron status in relation to breast cancer risk. Using random-effects meta-analyses,

SUBMITTER: Chang VC 

PROVIDER: S-EPMC6555759 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature