Implementation of genomics in medical practice to deliver precision medicine for an Asian population.

ABSTRACT: Whilst the underlying principles of precision medicine are comparable across the globe, genomic references, health practices, costs and discrimination policies differ in Asian settings compared to the reported initiatives involving European-derived populations. We have addressed these variables by developing an evolving reference base of genomic and phenotypic data and a framework to return medically significant variants to consenting research participants applicable for the Asian context. Targeting 10,000 participants, over 2000 Singaporeans, with no known pre-existing health conditions, have consented to an extensive clinical health screen, family health history collection, genome sequencing and ongoing follow-up. Genomic variants in a subset of genes associated with Mendelian disorders

SUBMITTER: Bylstra Y 

PROVIDER: S-EPMC6555782 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature