Fabrication of Hybrid Nanostructures Based on Fe₃O₄ Nanoclusters as Theranostic Agents for Magnetic Resonance Imaging and Drug Delivery.

ABSTRACT: Combining anticancer drugs with inorganic nanocrystals to construct multifunctional hybrid nanostructures has become a powerful tool for cancer treatment and tumor suppression. However, it remains a critical challenge to synthesize compact, multifunctional nanostructures with improved functionality and reproducibility. In this study, we report the fabrication of magnetite hybrid nanostructures employing Fe₃O₄ nanoparticles (NPs) to form multifunctional magnetite nanoclusters (NCs) by combining an oil-in-water microemulsion assembly and a layer-by-layer (LBL) method. The Fe₃O₄ NCs were firstly prepared via a microemulsion self-assembly technique. Then, polyelectrolyte layers composed of poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styren

SUBMITTER: Zhao J 

PROVIDER: S-EPMC6555842 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature