Retinal and circulating miRNA expression patterns in diabetic retinopathy: An in silico and in vivo approach.

ABSTRACT:

Background and purpose

Diabetic retinopathy, a secondary complication of diabetes mellitus, can lead to irreversible vision loss. Currently, no treatment is approved for early phases of diabetic retinopathy. Modifications of the expression pattern of miRNAs could be involved in the early retinal damage of diabetic subjects. Therefore, we aimed at identification of dysregulated miRNAs-mRNA interactions that might be biomarkers and pharmacological targets for diagnosis and treatment of early diabetic retinopathy.

Methods

A focused set of miRNAs was predicted through a bioinformatic analysis accessing to Gene Expression Omnibus dataset and enrichment of information approach (GENEMANIA-Cytoscape). Identification of miRNAs-mRNA interactions was carried out with miRNET analysis. D

SUBMITTER: Platania CBM 

PROVIDER: S-EPMC6555853 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature