Inactivation of endothelial adenosine A_2A receptors protects mice from cerebral ischaemia-induced brain injury.

ABSTRACT:

Background and purpose

Inactivation of the gene for adenosine A_2A receptors (ADORA2A for humans and Adora2a for rodents) protects against brain injury in experimental stroke. However, the cell-specific pathogenic effects of A_2A receptors in thromboembolic stroke and the underlying mechanisms remain undefined. Here, we tested the hypothesis that inhibition of endothelial A_2A receptors after thromboembolic stroke improves post-stroke outcomes via down-regulation of inflammation.

Experimental approach

Thromboembolic stroke was induced by embolic middle cerebral artery occlusion in mice. Post-stroke outcomes were determined with neurological deficit scoring, infarct volume, inflammatory marker expression, brain leukocyte infiltration, blood-brain

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC6555863 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature