Soluble epoxide hydrolase modulates immune responses in activated astrocytes involving regulation of STAT3 activity.

ABSTRACT:

Background

Astrocyte activation is a common pathological feature in many brain diseases with neuroinflammation, and revealing the underlying mechanisms might shed light on the regulatory processes of the diseases. Recently, soluble epoxide hydrolase (sEH) has been proposed to affect neuroinflammation in brain injuries. However, the roles of astrocytic sEH in brains with neurodegeneration remain unclear.

Methods

The expression of astrocytic sEH in the brains of APPswe/PSEN1dE9 (APP/PS1) mice developing Alzheimer's disease (AD)-like pathology was evaluated by confocal imaging. LPS-activated primary astrocytes with mRNA silencing or overexpression of sEH were used to investigate its regulatory roles in astrocyte activation and the induction of pro-inflammatory markers. Primary

SUBMITTER: Hung CC 

PROVIDER: S-EPMC6555999 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature