Characterization of molecular scores and gene expression signatures in primary breast cancer, local recurrences and brain metastases.

ABSTRACT:

Background

Breast cancer is a leading cause of cancer-related death in women worldwide. Despite extensive studies in all areas of basic, clinical and applied research, accurate prognosis remains elusive, thus leading to overtreatment of many patients. Diagnosis could be improved by introducing multigene molecular scores in standard clinical practice. Several tests that work with formalin-fixed tissue have become routine. Molecular scores usually include several genes representing processes, response to oestrogens, progestogens and human epidermal growth factor receptor 2 (Her2), respectively, which are combined additively in single values. These multi-gene scores have the advantage of being more robust and reproducible than single-gene scores. Their utility may be further enhanced

SUBMITTER: Bustamante Eduardo M 

PROVIDER: S-EPMC6556009 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature