Dataset Information

Prognostic significance of serum aspartic transaminase in diffuse large B-cell lymphoma.

ABSTRACT:

Background

Liver function is routinely assessed in clinical practice as liver function tests provide sensitive indicators of hepatocellular injury. However, the prognostic value of enzymes that indicate hepatic injury has never been systematically investigated in lymphoma, including diffuse large B-cell lymphoma (DLBCL).

Methods

This study examined the prognostic value of baseline aspartic transaminase (AST) in DLBCL patients. The association between AST and clinical features was analyzed in 179 DLBCL patients treated from 2006 to 2016. All enrolled patients were treated with R-CHOP or R-CHOP-like chemotherapy. Log-rank test, univariable analysis, and subgroup analysis were performed to evaluate the impact of AST on survival.

Results

AST 33.3 U/L was considered to be the optimal threshold value for predicting prognosis. A higher AST level was associated with advanced stage (P = 0.001), poorer performance status (P = 0.014), elevated lactate dehydrogenase level (P < 0.0001), presence of B symptoms (P = 0.001), high-risk International Prognostic Index (IPI, IPI 3-5) (P = 0.002), non-germinal center B-cell subtypes (P = 0.038), hepatitis B virus surface antigen positivity (P = 0.045) and more extra nodal involvement (ENI, ENI ≥ 2) (P = 0.027). Patients with a higher AST level had a shorter overall survival (OS) (2-year OS rate, 53.6% vs. 83.6%, P < 0.001). Subgroup analysis indicated that higher AST levels have poorer prognostic values in patients without B symptoms and LDH positive groups.

Conclusion

A pretreatment AST level is associated with OS in DLBCL patients treated with R-CHOP or similar chemotherapy regimens. A high pretreatment AST level might be a reliable prognostic factor for predicting a dismal outcome in DLBCL patients. Serum AST levels may be investigated for use as an easily determinable, inexpensive biomarker for risk assessment in patients with DLBCL.

SUBMITTER: Lu TX

PROVIDER: S-EPMC6556027 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Publications

Prognostic significance of serum aspartic transaminase in diffuse large B-cell lymphoma.

Lu Ting-Xun TX Wu Shuang S Cai Dong-Yan DY Hong Ting-Ting TT Zhang Ying Y Gao Hua-Qiang HQ Hua Hai-Ying HY Wu Xiao-Hong XH

BMC cancer 20190608 1

<h4>Background</h4>Liver function is routinely assessed in clinical practice as liver function tests provide sensitive indicators of hepatocellular injury. However, the prognostic value of enzymes that indicate hepatic injury has never been systematically investigated in lymphoma, including diffuse large B-cell lymphoma (DLBCL).<h4>Methods</h4>This study examined the prognostic value of baseline aspartic transaminase (AST) in DLBCL patients. The association between AST and clinical features was ...[more]

PMID: 31176361

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Dataset Information

Prognostic significance of serum aspartic transaminase in diffuse large B-cell lymphoma.

Background

Methods

Results

Conclusion

Publications

Prognostic significance of serum aspartic transaminase in diffuse large B-cell lymphoma.

Similar Datasets

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