Axial symptoms predict mortality in patients with Parkinson disease and subthalamic stimulation.

ABSTRACT:

Objective

To characterize how disease progression is associated with mortality in a large cohort of patients with Parkinson disease (PD) with long-term follow-up after subthalamic nucleus deep brain stimulation (STN-DBS).

Methods

Motor and cognitive disabilities were assessed before and 1, 2, 5, and 10 years after STN-DBS in 143 consecutive patients with PD. We measured motor symptoms "off" and "on" levodopa and STN-DBS and recorded causes of death. We used linear mixed models to characterize symptom progression, including interactions between treatment conditions and time to determine how treatments changed efficacy. We used joint models to link symptom progression to mortality.

Results

Median observation time was 12 years after surgery, during which akinesia, rigidi

SUBMITTER: Lau B 

PROVIDER: S-EPMC6556086 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature