Abnormal thalamocortical network dynamics in migraine.

ABSTRACT:

Objective

To investigate the dynamic functional connectivity of thalamocortical networks in interictal migraine patients and whether clinical features are associated with abnormal connectivity.

Methods

We investigated dynamic functional network connectivity (dFNC) of the migraine brain in 89 interictal migraine patients and 70 healthy controls. We focused on the temporal properties of thalamocortical connectivity using sliding window cross-correlation, clustering state analysis, and graph-theory methods. Relationships between clinical symptoms and abnormal dFNC were evaluated using a multivariate linear regression model.

Results

Five dFNC brain states were identified to characterize and compare dynamic functional connectivity patterns. We demonstrated that migraineurs

SUBMITTER: Tu Y 

PROVIDER: S-EPMC6556096 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature