Multidimensional imaging techniques for prediction of treatment response in major depressive disorder.

ABSTRACT: A large number of studies have attempted to use neuroimaging tools to aid in treatment prediction models for major depressive disorder (MDD). Most such studies have reported on only one dimension of function and prediction at a time. In this study, we used three different tasks across domains of function (emotion processing, reward anticipation, and cognitive control, plus resting state connectivity completed prior to start of medication to predict treatment response in 13-36 adults with MDD. For each experiment, adults with MDD were prescribed only label duloxetine (all experiments), whereas another subset were prescribed escitalopram. We used a KeyNet (both Task derived masks and Key intrinsic Network derived masks) approach to targeting brain systems in a specific match to tasks. The mo

SUBMITTER: Langenecker SA 

PROVIDER: S-EPMC6556149 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature