C-H ¹⁸F-fluorination of 8-methylquinolines with Ag[¹⁸F]F.

ABSTRACT: This report describes a Pd-mediated C-H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[18F]F. To achieve this transformation, a new method was developed for the generation of Ag[18F]F using a sep-pak cartridge. The C-H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module.

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC6556205 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature