Metabolites related to renal function, immune activation, and carbamylation are associated with muscle composition in older adults.

ABSTRACT: Reduced skeletal muscle density in older adults is associated with insulin resistance, decreased physical function, and an increased all-cause mortality risk. To elucidate mechanisms that may underlie the maintenance of skeletal muscle density, we conducted a secondary analysis of previously published muscle composition and serum metabolomic data in 73 older adults (average age, 78y). Multivariable-adjusted linear regression was used to examine associations between 321 metabolites with muscle composition, defined as the ratio between normal density (NDM) with low density (LDM) thigh muscle cross sectional area (NDM/LDM). Sixty metabolites were significantly (p≤0.05 and q<0.30) associated with NDM/LDM. Decreased renal function and the immune response have been previously linked with reduced

SUBMITTER: Lustgarten MS 

PROVIDER: S-EPMC6556217 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature