Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor.

ABSTRACT: Successful pregnancy requires a tightly-regulated equilibrium of immune cell interactions at the maternal-fetal interface (i.e., the decidual tissues), which plays a central role in the inflammatory process of labor. Most of the innate immune cells in this compartment have been well characterized; however, adaptive immune cells are still under investigation. Herein, we performed immunophenotyping of the decidua basalis and decidua parietalis to determine whether exhausted and senescent T cells are present at the maternal-fetal interface and whether the presence of pathological (i.e., preterm) or physiological (i.e., term) labor and/or placental inflammation alter such adaptive immune cells. In addition, decidual exhausted T cells were sorted to test their functional status. We found that (

SUBMITTER: Slutsky R 

PROVIDER: S-EPMC6556261 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature