TDG Gene Polymorphisms and Their Possible Association with Colorectal Cancer: A Case Control Study.

ABSTRACT: Genetic alterations that might lead to colorectal cancer involve essential genes including those involved in DNA repair, inclusive of base excision repair (BER). Thymine DNA glycosylase (TDG) is one of the most well characterized BER genes that catalyzes the removal of thymine moieties from G/T mismatches and is also involved in many cellular functions, such as the regulation of gene expression, transcriptional coactivation, and the control of epigenetic DNA modification. Mutation of the TDG gene is implicated in carcinogenesis. In the present study, we aimed to investigate the association between TDG gene polymorphisms and their involvement in colon cancer susceptibility. One hundred blood samples were obtained from colorectal cancer patients and healthy contro

SUBMITTER: Reddy Parine N 

PROVIDER: S-EPMC6556271 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature