Integrative analysis of common genes and driver mutations implicated in hormone stimulation for four cancers in women.

ABSTRACT: Cancer is one of the leading cause of death of women worldwide, and breast, ovarian, endometrial and cervical cancers contribute significantly to this every year. Developing early genetic-based diagnostic tools may be an effective approach to increase the chances of survival and provide more treatment opportunities. However, the current cancer genetic studies are mainly conducted independently and, hence lack of common driver genes involved in cancers in women. To explore the potential common molecular mechanism, we integrated four comprehensive literature-based databases to explore the shared implicated genetic effects. Using a total of 460 endometrial, 2,068 ovarian, 2,308 breast and 537 cervical cancer-implicated genes, we identified 52 genes which are common in all four types of cancer

SUBMITTER: Bhyan SB 

PROVIDER: S-EPMC6556371 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature