Experimental and computational framework for a dynamic protein atlas of human cell division.

ABSTRACT: Essential biological functions, such as mitosis, require tight coordination of hundreds of proteins in space and time. Localization, the timing of interactions and changes in cellular structure are all crucial to ensure the correct assembly, function and regulation of protein complexes^1-4. Imaging of live cells can reveal protein distributions and dynamics but experimental and theoretical challenges have prevented the collection of quantitative data, which are necessary for the formulation of a model of mitosis that comprehensively integrates information and enables the analysis of the dynamic interactions between the molecular parts of the mitotic machinery within changing cellular boundaries. Here we generate a canonical model of the morphological changes during the mitotic pr

SUBMITTER: Cai Y 

PROVIDER: S-EPMC6556381 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature