17β-Estradiol protects the esophageal epithelium from IL-13-induced barrier dysfunction and remodeling.

ABSTRACT:

Background

The incidence of eosinophilic esophagitis (EoE) is greater in male than female subjects, and the underlying molecular basis for this sex bias remains unclear.

Objective

We sought to delineate the contribution of the sex hormone estrogen to the EoE phenotype and esophageal epithelial barrier function and remodeling.

Methods

We performed demographic and incidence analyses of EoE in male and female subjects from a single-center pediatric cohort. Estrogen-responsive gene expression analyses and estrogen receptor (ESR) immunofluorescence staining of esophageal biopsy specimens from patients with EoE and control subjects were performed. The effect of 17β-estradiol (E2) on IL-13-induced signaling pathways, gene expression, and esophageal epithelial architecture an

SUBMITTER: Wheeler JC 

PROVIDER: S-EPMC6556402 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature