DNA methylation studies of depression with onset in the peripartum: A critical systematic review.

ABSTRACT:

Objective

Major depression with peripartum onset (MDP) has been associated with multiple adverse offspring health outcomes. The biological mechanisms underlying this relationship remain unclear, but DNA methylation (DNAm) represents a plausible mechanism for mediating MDP exposures and changes in offspring development, behavior, and health. Advances in DNAm research necessitate reevaluating the MDP-DNAm literature to determine how well past studies conform with current best practices.

Method

Five databases were searched to identify studies of prenatal-onset MDP and DNAm. Quality scores were assigned to each article independently by two raters using a novel scale specific for MDP-DNAm research.

Results

Nineteen studies met inclusion criteria. Quality scores ranged from

SUBMITTER: Braun SE 

PROVIDER: S-EPMC6556411 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature