Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva.

ABSTRACT: BACKGROUND:Epigenetic clocks have been suggested to capture one feature of the complexity between aging and the epigenome. However, little is known about the epigenetic clock in childhood allergy and asthma. OBJECTIVE:We sought to examine associations of DNA methylation age (DNAmAge) and epigenetic age acceleration with childhood allergy and asthma. METHODS:We calculated DNAmAge and age acceleration at birth, early childhood, and midchildhood based on the IlluminaHumanMethylation450BeadChip in Project Viva. We evaluated epigenetic clock associations with allergy and asthma using covariate-adjusted linear and logistic regressions. We attempted to replicate our findings in the Genetics of Asthma in Costa Rica Study. RESULTS:At midchildhood (mean age, 7.8 years) in Project Viva, DNAmAge and a

SUBMITTER: Peng C 

PROVIDER: S-EPMC6556426 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature