EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.

ABSTRACT: The ability of cells to perceive and translate versatile cues into differential chromatin and transcriptional states is critical for many biological processes^1-5. In plants, timely transition to a flowering state is crucial for successful reproduction^6-9. EARLY BOLTING IN SHORT DAY (EBS) is a negative transcriptional regulator that prevents premature flowering in Arabidopsis thaliana^10,11. We found that EBS contains bivalent bromo-adjacent homology (BAH)-plant homeodomain (PHD) reader modules that bind H3K27me3 and H3K4me3, respectively. We observed co-enrichment of a subset of EBS-associated genes with H3K4me3, H3K27me3, and Polycomb repressor complex 2 (PRC2). Notably, EBS adopted an autoinhibition mode to mediate its switch in binding preference between

SUBMITTER: Yang Z 

PROVIDER: S-EPMC6556434 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature