NMR metabolomics identifies over 60 biomarkers associated with Type II Diabetes impairment in db/db mice.

ABSTRACT:

Introduction

The rapid expansion of Type 2 Diabetes (T2D), that currently affects 90% of people suffering from diabetes, urges us to develop a better understanding of the metabolic processes involved in the disease process in order to develop better therapies. The most commonly used model for T2D research is the db/db (BKS.Cg-Dock7 < m > +/+ Lepr < db >/J) mouse model. Yet, a systematic ¹H NMR based metabolomics characterisation of most tissues in this animal model has not been published. Here, we provide a systematic organ-specific metabolomics analysis of this widely employed model using NMR spectroscopy.

Objectives

The aim of this study was to characterise the metabolic modulations associated with T2D in db/db mice in 18 relevant biological matrices.

Methods

SUBMITTER: Mora-Ortiz M 

PROVIDER: S-EPMC6556514 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature