Reproduction and longevity: A Mendelian randomization study of gonadotropin-releasing hormone and ischemic heart disease.

ABSTRACT:

Background

According to well-established evolutionary biology theory there is a trade-off between reproduction and longevity, implying that upregulating the reproductive axis might drive major diseases. We assessed whether the central driver of reproduction gonadotropin-releasing hormone 1 (GnRH1) had a causal effect on the leading cause of global morbidity and mortality, i.e. ischemic heart disease (IHD). As a contrast we similarly examined the role of GnRH2 because it is more a driver of female sexual behavior.

Methods

We applied strong (p-value <5 × 10^-6) and independent genetic predictors of GnRH1 and GnRH2 to an extensively genotyped IHD case (n = 76,014) - control (n = 264,785) study and combined the genetic variant specific Wald estimates using inverse vari

SUBMITTER: Schooling CM 

PROVIDER: S-EPMC6556548 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature