Discovery of an RmlC/D fusion protein in the microalga <i>Prymnesium parvum</i> and its implications for NDP-β-l-rhamnose biosynthesis in microalgae.

ABSTRACT: The 6-deoxy sugar l-rhamnose (l-Rha) is found widely in plant and microbial polysaccharides and natural products. The importance of this and related compounds in host-pathogen interactions often means that l-Rha plays an essential role in many organisms. l-Rha is most commonly biosynthesized as the activated sugar nucleotide uridine 5'-diphospho-β-l-rhamnose (UDP-β-l-Rha) or thymidine 5'-diphospho-β-l-rhamnose (TDP-β-l-Rha). Enzymes involved in the biosynthesis of these sugar nucleotides have been studied in some detail in bacteria and plants, but the activated form of l-Rha and the corresponding biosynthetic enzymes have yet to be explored in algae. Here, using sugar-nucleotide profiling in two representative algae, Euglena gracilis and the toxin-producing microalga Prymnesium p

SUBMITTER: Wagstaff BA 

PROVIDER: S-EPMC6556577 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature