Dihydronicotinamide riboside is a potent NAD⁺ concentration enhancer in vitro and in vivo.

ABSTRACT: Interest in pharmacological agents capable of increasing cellular NAD⁺ concentrations has stimulated investigations of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). NR and NMN require large dosages for effect. Herein, we describe synthesis of dihydronicotinamide riboside (NRH) and the discovery that NRH is a potent NAD⁺ concentration-enhancing agent, which acts within as little as 1 h after administration to mammalian cells to increase NAD⁺ concentrations by 2.5-10-fold over control values. Comparisons with NR and NMN show that in every instance, NRH provides greater NAD⁺ increases at equivalent concentrations. NRH also provides substantial NAD⁺ increases in tissues when administered by intraperitoneal injection to

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6556581 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature