Impact of the frequency of plasma viral load monitoring on treatment outcomes among children with perinatally acquired HIV.

ABSTRACT:

Introduction

Recommendations on the optimal frequency of plasma viral load (pVL) monitoring in children living with HIV (CLWH) who are stable on combination antiretroviral therapy (cART) are inconsistent. This study aimed to determine the impact of annual versus semi-annual pVL monitoring on treatment outcomes in Asian CLWH.

Methods

Data on children with perinatally acquired HIV aged <18 years on first-line, non-nucleoside reverse transcriptase inhibitor-based cART with viral suppression (two consecutive pVL <400 copies/mL over a six-month period) were included from a regional cohort study; those exposed to prior mono- or dual antiretroviral treatment were excluded. Frequency of pVL monitoring was determined at the site-level based on the median rate of pVL measurement: annu

SUBMITTER: Sudjaritruk T 

PROVIDER: S-EPMC6556679 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature