Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population.

ABSTRACT: Oesophageal squamous cell carcinoma (OSCC) has a high incidence in southern Africa and a poor prognosis. Limited information is available on the contribution of genetic variants in susceptibility to OSCC in this region. However, recent genome-wide association studies have identified multiple susceptibility loci in Asian and European populations. In this study, we investigated genetic variants from seven OSCC risk loci identified in non-African populations for association with OSCC in the South African Black population. We performed association studies in a total of 1471 cases and 1791 controls from two study sample groups, which included 591 cases and 852 controls from the Western Cape and 880 cases and 939 controls from the Johannesburg region in the Gauteng province. Thereafter, we perfo

SUBMITTER: Chen WC 

PROVIDER: S-EPMC6556703 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature