Integrated omics profiling reveals novel patterns of epigenetic programming in cancer-associated myofibroblasts.

ABSTRACT: There is increasing evidence that stromal myofibroblasts play a key role in the tumour development however, the mechanisms by which they become reprogrammed to assist in cancer progression remain unclear. As cultured cancer-associated myofibroblasts (CAMs) retain an ability to enhance the proliferation and migration of cancer cells in vitro, it is possible that epigenetic reprogramming of CAMs within the tumour microenvironment may confer long-term pro-tumourigenic changes in gene expression. This study reports the first comparative multi-omics analysis of cancer-related changes in gene expression and DNA methylation in primary myofibroblasts derived from gastric and oesophageal tumours. In addition, we identify novel CAM-specific DNA methylation signatures, which are not observed in patie

SUBMITTER: Najgebauer H 

PROVIDER: S-EPMC6556705 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature