Formation of multimeric steroid metal adducts and implications for isomer mixture separation by traveling wave ion mobility spectrometry.

ABSTRACT: Steroid analysis is essential to the fields of medicine and forensics, but such analyses can present some complex analytical challenges. While chromatographic methods require long acquisition times and often provide incomplete separation, ion mobility spectrometry (IMS) as coupled to mass spectrometry (MS) has demonstrated significant promise for the separation of steroids, particularly in concert with metal adduction and multimerization. In this study, traveling wave ion mobility spectrometry (TWIMS) was employed to separate multimer steroid metal adducts of isomers in mixtures. The results show the ability to separate steroid isomers with a decrease in resolution compared with single component standards because of the formation of heteromultimers. Additionally, ion-neutral collision cros

SUBMITTER: Rister AL 

PROVIDER: S-EPMC6556764 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature