Menopause and Risk of Kidney Stones.

ABSTRACT:

Purpose

Metabolic changes due to menopause may alter urine composition and kidney stone risk but results of prior work on this association have been mixed. We examined menopause and the risk of incident kidney stones, and changes in 24-hour urine composition in the NHS (Nurses' Health Study) II.

Materials and methods

Using multivariate adjusted Cox proportional hazards models we prospectively analyzed 108,639 NHS II participants who provided information on menopause and kidney stones. We also analyzed 24-hour urine collections from 658 participants who performed a collection while premenopausal and a repeat collection after menopause.

Results

During 22 years of followup there were 3,456 incident kidney stones. The multivariate adjusted relative risk of an incident kid

SUBMITTER: Prochaska M 

PROVIDER: S-EPMC6556766 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature