TSPO-PET and diffusion-weighted MRI for imaging a mouse model of infiltrative human glioma.

ABSTRACT: BACKGROUND:Glioblastoma (GBM) is the most devastating brain tumor. Despite the use of multimodal treatments, most patients relapse, often due to the highly invasive nature of gliomas. However, the detection of glioma infiltration remains challenging. The aim of this study was to assess advanced PET and MRI techniques for visualizing biological activity and infiltration of the tumor. METHODS:Using multimodality imaging, we investigated [18F]DPA-714, a radiotracer targeting the 18 kDa translocator protein (TSPO), [18F]FET PET, non-Gaussian diffusion MRI (apparent diffusion coefficient, kurtosis), and the S-index, a composite diffusion metric, to detect tumor infiltration in a human invasive glioma model. In vivo imaging findings were confirmed by autoradiography and immunofluorescence. RESUL

SUBMITTER: Pigeon H 

PROVIDER: S-EPMC6556856 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature