IProt-Sub: a comprehensive package for accurately mapping and predicting protease-specific substrates and cleavage sites.

ABSTRACT: Regulation of proteolysis plays a critical role in a myriad of important cellular processes. The key to better understanding the mechanisms that control this process is to identify the specific substrates that each protease targets. To address this, we have developed iProt-Sub, a powerful bioinformatics tool for the accurate prediction of protease-specific substrates and their cleavage sites. Importantly, iProt-Sub represents a significantly advanced version of its successful predecessor, PROSPER. It provides optimized cleavage site prediction models with better prediction performance and coverage for more species-specific proteases (4 major protease families and 38 different proteases). iProt-Sub integrates heterogeneous sequence and structural features and uses a two-step feature selecti

SUBMITTER: Song J 

PROVIDER: S-EPMC6556904 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature